Targeting tumor microenvironment for cancer therapy
C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation
Adaptive therapy is a dynamic cancer treatment protocol that updates (or 'adapts') treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …
Microfluidic tissue engineering and bio‐actuation
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment
Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …
metastases make the development of new therapies necessary. Colon cancer stem cells …
Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …
disease. To overcome the major challenges in cancer therapy, we need to have a better …
A review of microfluidic approaches for investigating cancer extravasation during metastasis
Metastases, or migration of cancers, are common and severe cancer complications.
Although the 5-year survival rates of primary tumors have greatly improved, those of …
Although the 5-year survival rates of primary tumors have greatly improved, those of …
Recent advances and future perspectives on microfluidic liquid handling
The interdisciplinary research field of microfluidics has the potential to revolutionize current
technologies that require the handling of a small amount of fluid, a fast response, low costs …
technologies that require the handling of a small amount of fluid, a fast response, low costs …