All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Human skin and hair color are visible traits that can vary dramatically within and across
ethnic populations. The genetic makeup of these traits—including polymorphisms in the …

The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is
limited by primary and acquired resistance. The molecular determinants of the resistance …

Growth regulation by estrogen in breast cancer 1 (GREB1) is involved in hormone-
dependent and-independent tumor development (eg, hepatoblastoma). In this study, we …

Cutaneous melanoma (CM) and uveal melanoma (UM) derive from cutaneous and uveal
melanocytes that share the same embryonic origin and display the same cellular function …

There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of
novel therapeutic modalities. Here, we discuss the current state of the art of melanoma …

Cutaneous melanoma arises from melanocytes following genetic, epigenetic and
allogenetic (ie other than epi/genetic) modifications. An estimated 10% of cutaneous …

Melanoma is an aggressive neoplasia issued from the malignant transformation of
melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of …

Melanocytes evolved to produce the melanin that gives colour to our hair, eyes and skin.
The melanocyte lineage also gives rise to melanoma, the most lethal form of skin cancer …

Phenotypic plasticity and subsequent generation of intratumoral heterogeneity underly key
traits in malignant melanoma such as drug resistance and metastasis. Melanoma plasticity …