[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

LM O'Connor, BA O'Connor, SB Lim, J Zeng… - Journal of …, 2023 - Elsevier
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Mechanisms underlying neurodegenerative disorders and potential neuroprotective activity of agrifood by-products

C Angeloni, M Malaguti, C Prata, M Freschi… - Antioxidants, 2022 - mdpi.com
Neurodegenerative diseases, characterized by progressive loss in selected areas of the
nervous system, are becoming increasingly prevalent worldwide due to an aging population …

[HTML][HTML] LPS-induced acute neuroinflammation, involving interleukin-1 beta signaling, leads to proteomic, cellular, and network-level changes in the prefrontal cortex …

D Mittli, V Tukacs, L Ravasz, É Csősz, T Kozma… - Brain, Behavior, & …, 2023 - Elsevier
Neuroinflammation induced by peripheral infections leads to various neuropsychiatric
symptoms both in humans and laboratory animals, eg, to the manifestation of sickness …

Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies

D Olešová, D Dobešová, P Majerová… - Journal of …, 2024 - Springer
Background Accumulation of tau leads to neuroinflammation and neuronal cell death in
tauopathies, including Alzheimer's disease. As the disease progresses, there is a decline in …

Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota …

X Wang, T Zhang, W Li, M Zhang, L Zhao… - Frontiers in …, 2024 - frontiersin.org
Introduction The prevention and mitigation of intestinal immune challenge is crucial for
poultry production. This study investigated the effects of dietary Macleaya cordata extract …

[HTML][HTML] Fisetin attenuates AlCl3-induced neurodegeneration by modulating oxidative stress and inflammatory cytokine release in adult albino wistar rats.

E Anyanwu, J Nwachukwu, K Obasi, P Ekwueme… - Toxicology Reports, 2024 - Elsevier
Aim Natural flavonoids have powerful antioxidant and anti-inflammatory activities against
neurodegenerative diseases. Fisetin is a powerful flavonoid that targets a variety of …

[PDF][PDF] Neuroinflammaging: A tight line between normal aging and age-related neurodegenerative disorders

L Soraci, A Corsonello, E Paparazzo, A Montesanto… - Aging Dis, 2024 - researchgate.net
Aging in the healthy brain is characterized by a low-grade, chronic, and sterile inflammatory
process known as neuroinflammaging. This condition, mainly consisting in an up-regulation …

Wide metabolite coverage LC-MS/MS assay for the diagnosis of inherited metabolic disorders in urine

E Ivanovová, B Piskláková, D Dobešová, H Janečková… - Talanta, 2024 - Elsevier
Objective The laboratory diagnosis of inherited metabolic disorders (IMD) has undergone
significant development in recent decades, mainly due to the use of mass spectrometry …

Activity of microbial-derived phenolic acids and their conjugates against LPS-induced damage in neuroblastoma cells and macrophages

D González de Llano, M Roldán, L Parro, B Bartolomé… - Metabolites, 2023 - mdpi.com
The aim of this study was to investigate whether microbial-derived phenolic acids, 3, 4-
dihydroxyphenylacetic (DHPA), protocatechuic acid (PCA), and dihydrocaffeic acid (DHCFA) …

Subclinical peripheral inflammation has systemic effects impacting central nervous system proteome in budgerigars

E Voukali, D Divín, MG Samblas, NK Veetil… - Developmental & …, 2024 - Elsevier
Regulation of neuroimmune interactions varies across avian species. Little is presently
known about the interplay between periphery and central nervous system (CNS) in parrots …