Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
TGF-β1 signaling and tissue fibrosis
KK Kim, D Sheppard… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …
wound repair in many organs. However, the outcome of temporary extracellular matrix …
Post-COVID-19 pulmonary fibrosis: novel sequelae of the current pandemic
SR Ambardar, SL Hightower, NA Huprikar… - Journal of clinical …, 2021 - mdpi.com
Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the
COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As …
COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As …
Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis
Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
Reactive oxygen species and fibrosis: further evidence of a significant liaison
K Richter, T Kietzmann - Cell and tissue research, 2016 - Springer
Age-related diseases such as obesity, diabetes, non-alcoholic fatty liver disease, chronic
kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the …
kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the …
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary
response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin …
response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin …
Endoplasmic reticulum stress in pulmonary fibrosis
A Burman, H Tanjore, TS Blackwell - Matrix Biology, 2018 - Elsevier
Endoplasmic reticulum (ER) stress is associated with development and progression of
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …
fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated …
Autophagy in idiopathic pulmonary fibrosis
AS Patel, L Lin, A Geyer, JA Haspel, CH An, J Cao… - PloS one, 2012 - journals.plos.org
Background Autophagy is a basic cellular homeostatic process important to cell fate
decisions under conditions of stress. Dysregulation of autophagy impacts numerous human …
decisions under conditions of stress. Dysregulation of autophagy impacts numerous human …