Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Regulation of primary micro RNA processing

A Creugny, A Fender, S Pfeffer - FEBS letters, 2018 - Wiley Online Library
Micro RNA s (mi RNA s) are evolutionarily conserved small regulatory RNA s that participate
in the adjustment of many, if not all, fundamental biological processes. Molecular …

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1

H Kooshapur, NR Choudhury, B Simon… - Nature …, 2018 - nature.com
Post-transcriptional mechanisms play a predominant role in the control of microRNA
(miRNA) production. Recognition of the terminal loop of precursor miRNAs by RNA-binding …

Post‐transcriptional regulation of polycistronic microRNAs

M Vilimova, S Pfeffer - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
An important proportion of microRNA (miRNA) genes tend to lie close to each other within
animal genomes. Such genomic organization is generally referred to as miRNA clusters …

Breast cancer subtype-specific mirnas: networks, impacts, and the potential for intervention

RP Arun, HF Cahill, P Marcato - Biomedicines, 2022 - mdpi.com
The regulatory and functional roles of non-coding RNAs are increasingly demonstrated as
critical in cancer. Among non-coding RNAs, microRNAs (miRNAs) are the most well-studied …

The role of structure in regulatory RNA elements

JN Tants, A Schlundt - Bioscience reports, 2024 - portlandpress.com
Regulatory RNA elements fulfill functions such as translational regulation, control of
transcript levels, and regulation of viral genome replication. Trans-acting factors (ie, RNA …

Enhanced TROSY Effect in [2‐19F, 2‐13C] Adenosine and ATP Analogs Facilitates NMR Spectroscopy of Very Large Biological RNAs in Solution

F Juen, D Glänzer, R Plangger, V Kugler… - Angewandte …, 2024 - Wiley Online Library
Large RNAs are central to cellular functions, but characterizing such RNAs remains
challenging by solution NMR. We present two labeling technologies based on [2‐19F, 2 …

Conformational effects of a cancer-linked mutation in pri-miR-30c RNA

AN Jones, A Walbrun, F Falleroni, M Rief… - Journal of Molecular …, 2022 - Elsevier
MicroRNAs (miRNAs) are small, noncoding RNAs that mediate post-transcriptional
downregulation of specific target genes. These transcripts are the products of a two-step …

SRSF3 shapes the structure of miR‐17‐92 cluster RNA and promotes selective processing of miR‐17 and miR‐20a

M Ratnadiwakara, MNM Bahrudeen, E Aikio… - EMBO …, 2023 - embopress.org
MicroRNA (miRNA) biogenesis is tightly regulated to maintain distinct miRNA expression
patterns. Almost half of mammalian miRNAs are generated from miRNA clusters, but this …

Solution structure of NPSL2, a regulatory element in the oncomiR-1 RNA

Y Liu, A Munsayac, I Hall, SC Keane - Journal of molecular biology, 2022 - Elsevier
The miR-17∼ 92a polycistron, also known as oncomiR-1, is commonly overexpressed in
multiple cancers and has several oncogenic properties. OncomiR-1 encodes six constituent …