Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell
stimulation, specific kinases are transiently phosphorylated and activated. Several of these …

A rapid increase in the synthesis of lipid-derived second messengers with subsequent
activation of protein phosphorylation cascades has emerged as one of the fundamental …

[Frontiers in Bioscience 3, d1134-1147, November 1, 1998] 1134 SIGNALING THROUGH
PROTEIN KINASE C Alex Toker Signal Transduction Page 1 [Frontiers in Bioscience 3 …

Protein kinase D (PKD) participates in activation of the transcription factor NF-κB (nuclear
factor κB) in cells exposed to oxidative stress, leading to increased cellular survival. We …

Recent research has identified protein kinase D (PKD, also called PKCmu) as a
serine/threonine kinase with potentially important roles in growth factor signaling as well as …

Activation of the serine kinase protein kinase D (PKD)/PKCμ is controlled by the
phosphorylation of two serine residues within its activation loop via a PKC-dependent …

Members of the protein kinase C (PKC) family of serine/threonine kinases are thought to
play critical roles in the regulation of cellular differentiation and proliferation in many cell …

Mast cells are activated by cross-linking of the high-affinity FcεRI receptor, initiated by the
binding of multivalent antigen to prebound IgE molecules in the receptor complex. Once …

Signal transduction pathways through protein kinase C (PKC) may playa significant role in
DNA synthesis and proliferation of human pancreatic cancers. Treatment of human …

Protein kinase C (PKC), a family of lipid-activated serine kinases, is involved in multiple
functions in the regulation of growth control. The PKC-related isoform PKCμ/PKD has been …