Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

Y Chen, X Du, A Kuppa, MF Feitosa, LF Bielak… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …

Multiomics study of nonalcoholic fatty liver disease

G Sveinbjornsson, MO Ulfarsson, RB Thorolfsdottir… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …

Comprehensive genetic study of the insulin resistance marker TG: HDL-C in the UK Biobank

A Oliveri, RJ Rebernick, A Kuppa, A Pant, Y Chen… - Nature …, 2024 - nature.com
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological …

M Vujkovic, S Ramdas, KM Lorenz, X Guo, R Darlay… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …

What is new in metabolic dysfunction-associated Steatotic liver disease in lean individuals: from bench to bedside

P Danpanichkul, K Suparan, D Kim… - Journal of Clinical …, 2024 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects more than 30% of
the world's adult population. While it is associated with obesity and metabolic syndrome …

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease

N Ghodsian, E Abner, CA Emdin, E Gobeil, N Taba… - Cell Reports …, 2021 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic
diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating …

PNPLA3 genotype and diabetes identify patients with nonalcoholic fatty liver disease at high risk of incident cirrhosis

VL Chen, A Oliveri, MJ Miller, K Wijarnpreecha, X Du… - Gastroenterology, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) can progress to cirrhosis and
hepatic decompensation, but whether genetic variants influence the rate of progression to …

A comparative study of effects of curcumin and its nanoparticles on the growth, immunity and heat stress resistance of Nile tilapia (Oreochromis niloticus)

HM Abdel-Ghany, DM El-Sisy, MES Salem - Scientific Reports, 2023 - nature.com
This study evaluated the effects of dietary supplementation with free-or nano-curcumin on
the growth performance, immune status and heat stress resistance of Nile tilapia …

Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study

SN Tang, V Zuber, KK Tsilidis - BMC medicine, 2022 - Springer
Background Only a few of the 34 biochemical biomarkers measured in the UK Biobank
(UKB) have been associated with breast cancer, with many associations suffering from …

Higher mortality among lean patients with non‐alcoholic fatty liver disease despite fewer metabolic comorbidities

K Wijarnpreecha, F Li, SK Lundin… - Alimentary …, 2023 - Wiley Online Library
Summary Background & Aims Non‐alcoholic fatty liver disease (NAFLD) can develop in
individuals who are not overweight. Whether lean persons with NAFLD have lower mortality …