Dementia is a complex set of disorders affecting normal cognitive function. Recently, several
clinical studies have shown that diabetes, obesity, and components of the metabolic …

The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Diabetes is a lifelong disease characterized by glucose metabolic imbalance, in which low
insulin levels or impaired insulin signaling lead to hyperglycemic state. Within 20 years of …

Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals.
Recent work has revealed that neurodegeneration occurs earlier than vascular insult and …

Neuropathic pain inflicts tremendous biopsychosocial suffering for patients worldwide.
However, safe and effective treatment of neuropathic pain is a prominent unmet clinical …

Diabetic neuropathy (DN) is a common complication of long-lasting type 1 and type 2
diabetes, with no curative treatment available. Here, we tested the effect of the incretin …

Visual function has been shown to deteriorate prior to the onset of retinopathy in some
diabetic patients and experimental animal models. This suggests the involvement of the …

We previously prepared ophthalmic formulations containing cilostazol (CLZ) nanoparticles
by bead mill methods (CLZnano), and found that instillation of CLZnano into rat eyes …

Glaucoma is one of the world's most frequent visual impairment causes and leads to
selective damage to retinal ganglion cells and their axons. Despite glaucoma's most …

An enriched environment (EE) constitutes a proficient strategy that instigates social,
cognitive, and motor faculties, fostering healing and heightening learning and memory …