Emerging evidence suggests that ascorbate, the dominant form of vitamin C under
physiological pH conditions, influences activity of the genome via regulating epigenomic …

The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …

The search for a connection between diet and human cancer has a long history in cancer
research, as has interest in the mechanisms by which dietary factors might increase or …

Researchers are intensifying efforts to understand the mechanisms by which changes in
metabolic states influence differentiation programs. An emerging objective is to define how …

High-grade serous ovarian cancer (HGSOC) harbours aberrant epigenetic features,
including DNA methylation. In this study we delineate pathways and networks altered by …

Vitamin C (L-ascorbic acid) is a micronutrient best known for its anti-scurvy activity in
humans. Vitamin C is involved in many biological processes involving enzymatic reactions …

BACKGROUND Both pluripotent stem cells (PSCs) and cancer cells have been described
as having similar metabolic pathways, most notably a penchant for favoring glycolysis even …

Epigenetic modifications, including DNA methylation and histone modifications, are involved
in regulation of gene expression, and alterations in these modifications are implicated in …

Witamina C (kwas L-askorbinowy) jest organicznym składnikiem odżywczym stosowanym w
zapobieganiu i leczeniu szkorbutu. Jest zaangażowana w wiele procesów biologicznych …

Modyfikacje epigenetyczne, do których zalicza się metylację DNA oraz modyfikacje
histonów są włączone w regulację ekspresji genów, a ich zaburzenia mogą się przyczynić …