This is the first comprehensive review on methods and materials for use in optical sensing of
pH values and on applications of such sensors. The Review starts with an introduction that …

Implantable neural interfaces advance the possibilities for neuroscientists to study the brain.
They are also promising for use in a multitude of bioelectronic therapies. Electrode …

Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

Using publicly available data sets, we compared pH in the human brain and the
cerebrospinal fluid (CSF) of postmortem control and Alzheimer's disease cases. We further …

It is usually assumed that individuals rest during sleep. However, coordinated neural activity
that presumably requires high energy consumption is increased during REM sleep. Here …

Converging evidence from molecular to neuroimaging studies suggests brain energy
metabolism abnormalities in both schizophrenia and bipolar disorder. One emerging …

The pH dynamics plays an important role in maintaining the homeostasis of the brain and is
related to a variety of brain diseases. Yet, there are many challenges in designing long-term …

Extracellular acidification occurs in the brain with elevated neural activity, increased
metabolism, and neuronal injury. This reduction in pH can have profound effects on brain …

Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly
mapped through the chemical exchange (CE) between glucose hydroxyl and water protons …

Adenosine 5'triphosphate (ATP) is a ubiquitous extracellular signaling messenger. Here, we
describe a method for in-vivo imaging of extracellular ATP with high spatiotemporal …