Informational density and relative accessibility of the peripheral nervous system make it an
attractive site for therapeutic intervention. Electrode-based electrophysiological interfaces …

Bioelectronic medicine (BM) is an emerging new approach for developing novel
neuromodulation therapies for pathologies that have been previously treated with …

Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory
bowel disease (IBD). However, side effects from cervical vagal nerve stimulation (VNS) are …

Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide
range of conditions, but effective translation requires increasing the efficacy and …

Introduction Electrical stimulation offers a drug-free alternative for the treatment of many
neurological conditions, such as chronic pain. However, it is not easy to selectively activate …

Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2
diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the …

Background. Peripheral nerve interfaces have emerged as alternative solutions for a variety
of therapeutic and performance improvement applications. The Defense Advanced …

Background Diarrhea is commonly associated with irritable bowel syndrome, inflammatory
bowel disease, microscopic colitis, and other gastrointestinal dysfunctions. Spontaneously …

Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disease. Despite
therapeutic advances, a significant proportion of RA patients are resistant to …

Real-time closed-loop control of neuromodulation devices requires long-term monitoring of
neural activity in the peripheral nervous system. Although many signal extraction methods …