Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19

N Bhalla, Y Pan, Z Yang, AF Payam - ACS nano, 2020 - ACS Publications
Biosensors and nanoscale analytical tools have shown huge growth in literature in the past
20 years, with a large number of reports on the topic of 'ultrasensitive','cost-effective', and …

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …

Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021 - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Bacterial adhesion at the single-cell level

C Berne, CK Ellison, A Ducret, YV Brun - Nature Reviews Microbiology, 2018 - nature.com
The formation of multicellular microbial communities, called biofilms, starts from the
adhesion of a few planktonic cells to the surface. The transition from a free-living planktonic …

Imaging modes of atomic force microscopy for application in molecular and cell biology

YF Dufrêne, T Ando, R Garcia, D Alsteens… - Nature …, 2017 - nature.com
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows
biological samples, from single molecules to living cells, to be visualized and manipulated …

Critical review on biofilm methods

J Azeredo, NF Azevedo, R Briandet… - Critical reviews in …, 2017 - Taylor & Francis
Biofilms are widespread in nature and constitute an important strategy implemented by
microorganisms to survive in sometimes harsh environmental conditions. They can be …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Rationally engineered nucleic acid architectures for biosensing applications

M Xiao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …