YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

YAP/TAZ at the roots of cancer

F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

YAP/TAZ signaling and resistance to cancer therapy

CDK Nguyen, C Yi - Trends in cancer, 2019 - cell.com
Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy

BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm

C Wang, X Zhu, W Feng, Y Yu, K Jeong… - American journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …

[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

F Szulzewsky, EC Holland, V Vasioukhin - Developmental biology, 2021 - Elsevier
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …

[HTML][HTML] The role of hippo pathway in cancer stem cell biology

JH Park, JE Shin, HW Park - Molecules and cells, 2018 - Elsevier
The biological significance and deregulation of the Hippo pathway during organ growth and
tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core …

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

O Dobrokhotov, M Samsonov, M Sokabe… - Clinical and translational …, 2018 - Springer
Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator
1 (TAZ) are important regulators of multiple cellular functions such as proliferation …

The Hippo pathway in normal development and cancer

M Maugeri-Saccà, R De Maria - Pharmacology & therapeutics, 2018 - Elsevier
The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

M Shibata, K Ham, MO Hoque - International journal of cancer, 2018 - Wiley Online Library
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …