The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …

ADP-ribosylation—the transfer of ADP-ribose (ADPr) from NAD+ onto target molecules—is
catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in …

ADP-ribosylation (ADPr) regulates important patho-physiological processes through its
attachment to different amino acids in proteins. Recently, by precision mapping on all …

Conventional ubiquitination involves the ATP-dependent formation of amide bonds between
the ubiquitin C terminus and primary amines in substrate proteins. Recently, SdeA, an …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

ADP-ribosylation (ADPr) is a biologically and clinically important post-translational
modification, but little is known about the amino acids it targets on cellular proteins. Here we …

Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Intracellular pathogens manipulate host organelles to support replication within cells. For
Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic …

Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected
mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic …

Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are
fundamental for creating the tools needed to explore this elusive post-translational …