Cells are equipped with a diverse network of signaling and regulatory proteins that function
as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell …

Translation regulation is critical for early mammalian embryonic development. However,
previous studies had been restricted to bulk measurements, precluding precise …

Early embryonic development is characterized by a plethora of very complex and
simultaneously operating processes, which are constantly changing cellular morphology …

Chromosome segregation errors occur frequently during female meiosis but also in the first
mitoses of mammalian preimplantation development. Such errors can lead to aneuploidy …

Aneuploidy in human embryos is surprisingly prevalent and increases drastically with
maternal age, resulting in miscarriages, infertility and birth defects. Frequent errors during …

Control mechanisms of spindle assembly and chromosome segregation are vital for
preventing aneuploidy during cell division. The mammalian germ cells and embryos are …

In recent years, we have witnessed an unprecedented advancement of light microscopy
techniques which has allowed us to better understand biological processes occurring during …

Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation
failure, or spontaneous miscarriage in both natural and assisted reproduction. Despite our …

The maternal to zygote transition in mammals has been an area of intensive research over
the past few decades, with an ever-changing landscape of understanding that has …

Chromosome segregation errors in mammalian embryos are common and jeopardize
embryo health. Here, we perform for the first time 4‐Dimensional imaging and tracking of …