The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

The authors present a steady-state-, particle-size-, and dose-dependent dissolution–
permeation model that describes particle dissolution within the concentration boundary layer …

This review focuses on options available to a pharmaceutical scientist to predict in vivo
supersaturation and precipitation of poorly water-soluble drugs. As no single device or …

Upon dissolution, amorphous solid dispersions (ASDs) of poorly water-soluble compounds
can generate supersaturated solutions consisting of bound and free drug species that are in …

The dissolution testing method described in the United States Pharmacopeia (USP)
Chapter⟨ 711⟩ is widely used for assessing the release of active pharmaceutical …

Abstract Dissolution-permeation (D/P) experiments are widely used during preclinical
development due to producing results with better predictability than traditional monophasic …

The aim of this work is to develop a novel simultaneous in vitro dissolution-in situ perfusion
system (SDPS) as a potential tool to evaluate the in vivo performance of solid oral …

Intestinal tissue or cell layers are of great interest to investigate the intestinal permeation
potential of drug compounds but their application in pharmaceutical industrial laboratories is …

Over the past three decades, high-throughput screening has resulted in a discovery pipeline
consisting mostly of highly potent but lipophilic compounds exhibiting poor aqueous …

Oral drug products must dissolve in the gastrointestinal (GI) tract before being absorbed and
reaching the systemic circulation. The rate and extent of drug dissolution and absorption …