The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Background Studies using positron emission tomography to image striatal dopamine
function, have demonstrated that individuals with schizophrenia display increases in …

Context Current drug treatments for schizophrenia are inadequate for many patients, and
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …

OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …

The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of
dopaminergic transmission at the D2 receptor. We measured in vivo occupancy of striatal D2 …

Context A major limitation on the development of biomarkers and novel interventions for
schizophrenia is that its pathogenesis is unknown. Although elevated striatal dopamine …

The data surveyed in this book suggest that psychiatric drug treatment is currently
administered on the basis of ahuge collective myth; the myth that psychiatric drugs act by …

Context A long-standing version of the dopamine hypothesis of schizophrenia postulates
that hyperactivity of dopaminergic transmission at D 2 receptors in the limbic striatum is …