Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

PK Ajikumar, K Tyo, S Carlsen, O Mucha… - Molecular …, 2008 - ACS Publications
Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

Biosynthesis of plant isoprenoids: perspectives for microbial engineering

J Kirby, JD Keasling - Annual review of plant biology, 2009 - annualreviews.org
Isoprenoids are a large and highly diverse group of natural products with many functions in
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …

Programming cells by multiplex genome engineering and accelerated evolution

HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest… - Nature, 2009 - nature.com
The breadth of genomic diversity found among organisms in nature allows populations to
adapt to diverse environments,. However, genomic diversity is difficult to generate in the …

Engineering central metabolic modules of Escherichia coli for improving β-carotene production

J Zhao, Q Li, T Sun, X Zhu, H Xu, J Tang, X Zhang… - Metabolic …, 2013 - Elsevier
ATP and NADPH are two important cofactors for production of terpenoids compounds. Here
we have constructed and optimized β-carotene synthetic pathway in Escherichia coli …

[HTML][HTML] Modular engineering for microbial production of carotenoids

C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …

Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants

S Wu, M Schalk, A Clark, RB Miles, R Coates… - Nature …, 2006 - nature.com
Terpenes constitute a distinct class of natural products1 that attract insects, defend against
phytopathogenic microbes and combat human diseases. However, like most natural …

Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids

HR Beller, TS Lee, L Katz - Natural product reports, 2015 - pubs.rsc.org
Covering: 2005 to 2015 Although natural products are best known for their use in medicine
and agriculture, a number of fatty acid-derived and isoprenoid natural products are being …

Efficient production of lycopene in Saccharomyces cerevisiae by enzyme engineering and increasing membrane flexibility and NAPDH production

J Hong, SH Park, S Kim, SW Kim, JS Hahn - Applied microbiology and …, 2019 - Springer
Lycopene is a red carotenoid pigment with strong antioxidant activity. Saccharomyces
cerevisiae is considered a promising host to produce lycopene, but lycopene toxicity is one …

Metabolic engineering for plant natural product biosynthesis in microbes

JA Chemler, MAG Koffas - Current opinion in biotechnology, 2008 - Elsevier
Plant natural products (NPs) not only serve many functions in an organism's survivability but
also demonstrate important pharmacological activities. Isolation of NPs from native sources …

An update on microbial carotenoid production: application of recent metabolic engineering tools

A Das, SH Yoon, SH Lee, JY Kim, DK Oh… - Applied microbiology and …, 2007 - Springer
Carotenoids are ubiquitous pigments synthesized by plants, fungi, algae, and bacteria.
Industrially, carotenoids are used in pharmaceuticals, neutraceuticals, and animal feed …