Cardiometabolic diseases exert a significant health impact, leading to a considerable
economic burden globally. The metabolic syndrome, characterized by a well-defined cluster …

Natural products are a boundless source for the development of pharmaceutical agents
against a wide range of human diseases. Accordingly, naturally occurring aurones possess …

Iron overload (IO) is known to contribute to metabolic dysfunctions such as type 2 diabetes
and insulin resistance. Using L6 skeletal muscle cells overexpressing the CDGSH iron …

Objective Ferritin, the principal iron storage protein, is essential to iron homeostasis. How
iron homeostasis affects the adipose tissue is not well understood. We investigated the role …

Abstract Purpose of Review Review the latest data regarding the intersection of adipose
tissue (AT) and iron to meet the needs of AT metabolism and the progression of related …

Aims Autophagy is an important cellular process for maintaining physiological homeostasis
and is known to protect against cardiovascular diseases including ischemia reperfusion (I/R) …

Aims Ferroptosis is a form of iron-regulated cell death implicated in ischemic heart disease.
Our previous study revealed that Sirtuin 3 (SIRT3) is associated with ferroptosis and cardiac …

Iron overload is a pathological condition characterized by the abnormal accumulation of iron
within the body, which may result from excessive iron intake, disorders of iron metabolism, or …

Background CISD-1 is a mitochondrial iron-sulfate [2Fe-2S] protein known to be associated
with various human diseases, including cancer and diabetes. Previously, we demonstrated …

The NET family member, CDGSH iron-sulfur domain-containing protein 1 (CISD1), is located
in the outer membrane of mitochondria, where it regulates energy and iron metabolism …