Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

The contribution of cell generation to physiological heart growth and maintenance in
humans has been difficult to establish and has remained controversial. We report that the full …

The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …

In a cell-free approach to regenerative therapeutics, transient application of paracrine factors
in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained …

The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell
types holds great promise for regenerative medicine. We reported previously that cardiac …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

The neonatal mammalian heart is capable of substantial regeneration following injury
through cardiomyocyte proliferation,. However, this regenerative capacity is lost by postnatal …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …