Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible …

Receptor tyrosine kinases (RTK s) are a large family of cell surface receptors that sense
growth factors and hormones and regulate a variety of cell behaviours in health and …

The generation of a functional nervous system involves a multitude of steps that are
controlled by just a few families of extracellular signaling molecules. Among these, the …

Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed
to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs …

Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian
brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the …

Fibrosis is a pathological condition that is characterized by the replacement of dead or
damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies …

Adiponectin is the most abundant adipokine secreted from adipocytes. Accumulating
evidence suggests that the physiological roles of adiponectin go beyond its metabolic …