Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
Interfacial enzymes enable gram-positive microbes to eat fatty acids
CD Radka - Membranes, 2023 - mdpi.com
Exogenous fatty acid (eFA) activation and utilization play key roles in bacterial physiology
and confer growth advantages by bypassing the need to make fatty acids for lipid synthesis …
and confer growth advantages by bypassing the need to make fatty acids for lipid synthesis …
Destruction of the cell membrane and inhibition of cell phosphatidic acid biosynthesis in Staphylococcus aureus: an explanation for the antibacterial mechanism of …
D Pang, S Liao, W Wang, L Mu, E Li, W Shen, F Liu… - Food & function, 2019 - pubs.rsc.org
Morusin is a prenylated flavonoid found in mulberry that shows antimicrobial activity against
foodborne pathogens. The MIC values of morusin toward S. aureus ATCC 6538 and S …
foodborne pathogens. The MIC values of morusin toward S. aureus ATCC 6538 and S …
FapR: from control of membrane lipid homeostasis to a biotechnological tool
D Albanesi, D De Mendoza - Frontiers in molecular biosciences, 2016 - frontiersin.org
Phospholipids and fatty acids are not only one of the major components of cell membranes
but also important metabolic intermediates in bacteria. Since the fatty acid biosynthetic …
but also important metabolic intermediates in bacteria. Since the fatty acid biosynthetic …
The stringent response plays a key role in Bacillus subtilis survival of fatty acid starvation
AA Pulschen, DE Sastre… - Molecular …, 2017 - Wiley Online Library
The stringent response is a universal adaptive mechanism to protect bacteria from nutritional
and environmental stresses. The role of the stringent response during lipid starvation has …
and environmental stresses. The role of the stringent response during lipid starvation has …
Membrane fluidity adjusts the insertion of the transacylase PlsX to regulate phospholipid biosynthesis in Gram-positive bacteria
PlsX plays a central role in the coordination of fatty acid and phospholipid biosynthesis in
Gram-positive bacteria. PlsX is a peripheral membrane acyltransferase that catalyzes the …
Gram-positive bacteria. PlsX is a peripheral membrane acyltransferase that catalyzes the …
Minimization of the Bacillus subtilis divisome suggests FtsZ and SepF can form an active Z-ring, and reveals the amino acid transporter BraB as a new cell division …
Bacterial cytokinesis begins with polymerization of the tubulin homologue FtsZ into a ring-
like structure at midcell, the Z-ring, which recruits the late cell division proteins that …
like structure at midcell, the Z-ring, which recruits the late cell division proteins that …
The phosphatidic acid pathway enzyme PlsX plays both catalytic and channeling roles in bacterial phospholipid synthesis
PlsX is the first enzyme in the pathway that produces phosphatidic acid in Gram-positive
bacteria. It makes acylphosphate from acyl-acyl carrier protein (acyl-ACP) and is also …
bacteria. It makes acylphosphate from acyl-acyl carrier protein (acyl-ACP) and is also …
Divisome minimization shows that FtsZ and SepF can form an active Z-ring, and reveals BraB as a new cell division influencing protein in Bacillus subtilis
One of the aims of synthetic biology is the construction of a minimal cell. Since bacteria are
the simplest life forms, they are the preferred blueprint for such a cell. In this study, we tried …
the simplest life forms, they are the preferred blueprint for such a cell. In this study, we tried …
Right place, right time: focalization of membrane proteins in Gram-positive bacteria
Membrane proteins represent a significant proportion of total bacterial proteins and perform
vital cellular functions ranging from exchanging metabolites and genetic material, secretion …
vital cellular functions ranging from exchanging metabolites and genetic material, secretion …