New SHIVs and improved design strategy for modeling HIV-1 transmission, immunopathogenesis, prevention, and cure
Previously, we showed that substitution of HIV-1 envelope (Env) residue 375-Ser by bulky
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to …
In Vivo Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian …
S Khanal, CM Fennessey, SP O'Brien, A Thorpe… - Journal of …, 2019 - Am Soc Microbiol
Genetically barcoded viral populations are powerful tools for evaluating the overall viral
population structure as well as assessing the dynamics and evolution of individual lineages …
population structure as well as assessing the dynamics and evolution of individual lineages …
Th17 T cells and immature dendritic cells are the preferential initial targets after rectal challenge with a simian immunodeficiency virus-based replication-defective dual …
D Maric, WA Grimm, N Greco, MD McRaven… - Journal of …, 2021 - Am Soc Microbiol
Understanding the earliest events of human immunodeficiency virus (HIV) sexual
transmission is critical to developing and optimizing HIV prevention strategies. To gain …
transmission is critical to developing and optimizing HIV prevention strategies. To gain …
The mucosal barrier and anti-viral immune responses can eliminate portions of the viral population during transmission and early viral growth
RV Moriarty, AE Golfinos, DD Gellerup, H Schweigert… - Plos one, 2021 - journals.plos.org
Little is known about how specific individual viral lineages replicating systemically during
acute Human Immunodeficiency Virus or Simian Immunodeficiency Virus (HIV/SIV) infection …
acute Human Immunodeficiency Virus or Simian Immunodeficiency Virus (HIV/SIV) infection …
Immune responses and viral persistence in simian/human immunodeficiency virus SHIV. C. CH848-infected rhesus macaques
Chimeric simian/human immunodeficiency viruses (SHIVs) are widely used in nonhuman
primate models to recapitulate human immunodeficiency virus (HIV) infection in humans, yet …
primate models to recapitulate human immunodeficiency virus (HIV) infection in humans, yet …
Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral …
W Ziani, J Shao, X Wang, K Russell-Lodrigue… - Journal of …, 2021 - Am Soc Microbiol
The human immunodeficiency virus (HIV) reservoir is responsible for persistent viral
infection, and a small number of mosaic latent cellular reservoirs promote viral rebound …
infection, and a small number of mosaic latent cellular reservoirs promote viral rebound …
A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain simian immunodeficiency virus epitope specificities
We have recently shown that MUC16, a component of the glycocalyx of some mucosal
barriers, has elevated binding to the G0 glycoform of the Fc portion of IgG. Therefore, IgG …
barriers, has elevated binding to the G0 glycoform of the Fc portion of IgG. Therefore, IgG …
Correction: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in …
RM Bochart, K Busman-Sahay, S Bondoc… - PLoS …, 2023 - journals.plos.org
The published article [1] presents data from two separate animal studies. The first study
conducted at the National Cancer Institute (NCI) comprised an 18-rhesus macaque (RM) …
conducted at the National Cancer Institute (NCI) comprised an 18-rhesus macaque (RM) …
Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility
Variations in the composition of the intestinal bacterial microbiome correlate with acquisition
of some sexually transmitted pathogens. To experimentally assess the contribution of …
of some sexually transmitted pathogens. To experimentally assess the contribution of …