Persistence has been linked to treatment failure since its discovery over 70 years ago and
understanding formation, nature and survival of this key antibiotic refractory subpopulation is …

Bacteria withstand antibiotic onslaughts by employing a variety of strategies, one of which is
persistence. Persistence occurs in a bacterial population where a subpopulation of cells …

Understanding evolution of antibiotic resistance is vital for containing its global spread. Yet
our ability to in situ track highly heterogeneous and dynamic evolution is very limited. Here …

Persister cells are growth-arrested subpopulations that can survive possible fatal
environments and revert to wild types after stress removal. Clinically, persistent pathogens …

Antibiotic persistence is a phenomenon observed when genetically susceptible cells survive
long-term exposure to antibiotics. These 'persisters' are an intrinsic component of bacterial …

Microbes have inherent capacities for utilizing various carbon sources, however they often
exhibit sub-par fitness due to low metabolic efficiency. To test whether a bacterial strain can …

Bacterial division is an inherently stochastic process with effects on fluctuations of protein
concentration and phenotype variability. Current modeling tools for the stochastic short-term …

The prevalence of bacterial persisters is related to their phenotypic diversity and is
responsible for the relapse of chronic infections. Tolerance to antibiotic therapy is the …

Due to their small size, microorganisms directly experience only a tiny portion of the
environmental heterogeneity manifested in the soil. The microscale variations in soil …

Spatial structure over scales ranging from nanometres to centimetres (and beyond) varies
markedly in diverse habitats and the industry-relevant settings that support microbial activity …