The sexes show profound differences in responses to infection and the development of
autoimmunity. Dimorphisms in immune responses are ubiquitous across taxa, from …

Viral pathogens present many challenges to organisms, driving the evolution of a myriad of
antiviral strategies to combat infections. A wide variety of viruses infect invertebrates …

Since its discovery, RNA interference has been identified as involved in many different
cellular processes, and as a natural antiviral response in plants, nematodes, and insects. In …

An active immune response is energetically demanding and requires reallocation of
nutrients to support resistance to and tolerance of infection. Insulin signaling is a critical …

Evolutionary ecologists frequently argue that parasite defence is costly because resources
must be reallocated from other life‐history traits to fuel the immune response. However, this …

Cysteine peptidases play a central role in the biology of Leishmania. In this work, we sought
to further elucidate the mechanism (s) by which the cysteine peptidase CPB contributes to L …

To gain a comprehensive view of the changes in host gene expression underlying Zika virus
(ZIKV) pathogenesis, we performed whole-genome RNA sequencing (RNA-seq) of ZIKV …

Zika virus (ZIKV) outbreaks pose a massive public health threat in several countries. We
have developed an in vivo model to investigate the host–ZIKV interaction in Drosophila. We …

Programmed cell death occurs in the germline of many organisms, both as an essential part
of development and throughout adult life. Germline cell death can be apoptotic or …

The bacterial symbiont Wolbachia can protect insects against viral pathogens, and the
varying levels of antiviral protection are correlated with the endosymbiont load within the …