The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and
physiological effects with significant implications for critical illness. Changes in respiratory …

There is a well-recognised importance for personalising mechanical ventilation settings to
protect the lungs and the diaphragm for each individual patient. Measurement of …

Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of
respiratory failure. Despite decades of research, there are no effective pharmacologic …

Although maintaining some amount of positive end-expiratory pressure (PEEP) seems
essential, selecting and titrating a specific level for patients with ARDS remains challenging …

Ventilator-induced lung injury (VILI) is a significant risk for patients with acute respiratory
distress syndrome (ARDS). Management of the patient with ARDS is currently dominated by …

Veno-venous extracorporeal membrane oxygenation (ECMO) is a helpful intervention in
patients with severe refractory hypoxemia either because mechanical ventilation cannot …

Background The superimposed pressure is the primary determinant of the pleural pressure
gradient. Obesity is associated with elevated end-expiratory esophageal pressure …

Background Esophageal pressure (Pes) can be used as a reliable surrogate for pleural
pressure, especially in critically ill patients requiring personalized mechanical ventilation …

Introduction Electrical impedance tomography (EIT) can be used to assess
ventilation/perfusion (V/Q) mismatch within the lungs. Several methods have been …

OBJECTIVES: Positive end-expiratory pressure and tidal volume may have a key role for the
outcome of patients with acute respiratory distress syndrome. The variety of acute respiratory …