Aptamers are oligonucleotides selected from large pools of random sequences based on
their affinity for bioactive molecules and are used in similar ways to antibodies. Aptamers …

Background Alzheimer disease (AD) research has focussed mainly on the amyloid beta
protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor …

Background: Neuroimaging bears the promise of providing new biomarkers that could refine
the diagnosis of dementia. Still, obtaining the pathology data required to validate the …

The monoclonal antibodies 6E10 and 4G8 are among the first anti-amyloid monoclonal
antibodies against Aß and the most widely used antibodies in Alzheimer's disease research …

β-Amyloid deposition is one of the main pathological features of Alzheimer's disease (AD).
The development of fluorescent probes targeting specific β-amyloid species has recently …

The accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark
of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small …

Recent investigations suggest that soluble oligomeric amyloid β (Aβ) species may be
involved in early onset of Alzheimer's disease (AD). Using systematic proline replacement …

Social interactions have a significant impact on health in humans and animal models. Social
isolation initiates a cascade of stress-related physiological disorders and stands as a …

Aggregations of β-amyloid (Aβ) and α-synuclein (αS) into oligomeric and fibrillar assemblies
are the pathological hallmarks of Alzheimer's and Parkinson's diseases, respectively …

Mutations in Cu/Zn-superoxide dismutase (SOD1) gene are linked to 10–20% of familial
amyotrophic lateral sclerosis (fALS) cases. The mutations cause misfolding and self …