Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …
regulatory domains of target proteins, which control a protein's stability. These regions …
Cytokinesis-block micronucleus cytome assay evolution into a more comprehensive method to measure chromosomal instability
M Fenech - Genes, 2020 - mdpi.com
This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its
evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei …
evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei …
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
S Sivakumar, GJ Gorbsky - Nature reviews Molecular cell biology, 2015 - nature.com
The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
C Alfieri, S Zhang, D Barford - Open biology, 2017 - royalsocietypublishing.org
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …
Building a regulatory network with short linear sequence motifs: lessons from the degrons of the anaphase-promoting complex
The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that
polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the …
polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the …
Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis
Highlights•Assignment of the complete secondary structure and subunit identification of the
APC/C.•Mechanism of D box and KEN box recognition by APC/C-coactivator complexes.• …
APC/C.•Mechanism of D box and KEN box recognition by APC/C-coactivator complexes.• …
Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2
S Hellmuth, L Gómez-H, AM Pendás, O Stemmann - Nature, 2020 - nature.com
Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle
assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion …
assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion …
PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit
J Kim, K Lee, K Rhee - Nature communications, 2015 - nature.com
Centrioles are duplicated and segregated in close link to the cell cycle. During mitosis,
daughter centrioles are disengaged and eventually separated from mother centrioles. New …
daughter centrioles are disengaged and eventually separated from mother centrioles. New …
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy
S Vakili-Samiani, OJ Khanghah, E Gholipour… - Mutation Research …, 2022 - Elsevier
Mitosis is the process of cell division and is regulated by checkpoints in the cell cycle. G1-S,
S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the …
S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the …
The RIF1-PP1 axis controls abscission timing in human cells
Abscission is the final step of cell division when the cytokinetic furrow ingresses completely,
leading to midbody formation and plasma membrane fission [1]. In human cells, the Aurora …
leading to midbody formation and plasma membrane fission [1]. In human cells, the Aurora …