The digital world is generating data at a staggering and still increasing rate. While these “big
data” have unlocked novel opportunities to understand public health, they hold still greater …

Background: Audience segmentation strategies are of increasing interest to public health
professionals who wish to identify easily defined, mutually exclusive population subgroups …

Background Efforts to develop an evidence-based approach to the evaluation and
management of young febrile infants have spanned more than 4 decades. 1 In the 1970s …

BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and
laboratory parameters, including procalcitonin, was recently described as an accurate tool in …

Blood culture contamination represents an ongoing source of frustration for clinicians and
microbiologists alike. Ambiguous culture results often lead to diagnostic uncertainty in …

Importance The procalcitonin (PCT) assay is an accurate screening test for identifying
invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are …

Objectives To evaluate current processes by which young children presenting with a febrile
illness but suspected of having serious bacterial infection are diagnosed and treated, and to …

Background: Management of febrile young infants suspected of having serious bacterial
infections has been a challenge for decades. The impact of changes in prenatal screening …

Background Our aim was to identify which clinical features have value in confirming or
excluding the possibility of serious infection in children presenting to ambulatory care …

Acute pyelonephritis is one of the most serious bacterial illnesses during childhood.
Escherichia coli is responsible in most cases, however other organisms including Klebsiella …