Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …

Recently, there has been an increasing interest in the development and characterization of
patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly …

Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of
hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour …

Oncology research in humans is limited to analytical and observational studies for obvious
ethical reasons, with therapy-focused clinical trials being the one exception to this rule …

Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for
treating multiple refractory blood cancers, but further advances are required for solid tumor …

Cisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness
seems to be due to the unique properties of cisplatin, which enters cells via multiple …

Although advances in genomics during the last decade have opened new avenues for
translational research and allowed the direct evaluation of clinical samples, there is still a …

Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination,
resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular …