MDM4 (also called MDMX) has been initially identified as p53 inhibitor. Subsequent data
have reinforced this role pointing to the requirement for MDM4 repressive activity on p53 for …

Rule-based modeling provides a means to represent cell signaling systems in a way that
captures site-specific details of molecular interactions. For rule-based models to be more …

FOXO transcription factors are an important, conserved family of regulators of cellular
processes including metabolism, cell-cycle progression, apoptosis and stress resistance …

The interaction of p53 with its regulators MDM2 and MDMX plays a major role in regulating
the cell cycle. Inhibition of this interaction has become an important therapeutic strategy in …

Epithelial ovarian cancer (EOC) is a highly heterogeneous disease with a high death rate
mainly due to the metastatic spread. The expression of MDM4, a well-known p53-inhibitor, is …

In this work we have further developed the Direct Computer Mapping (DCM) based
modelling and simulation methodology. A unified, transition-based representation of …

Abstract Background The Molecular Interaction Map (MIM) notation offers a standard set of
symbols and rules on their usage for the depiction of cellular signaling network diagrams …

In this paper, a p53-Mdm2 network model with Michaelis–Menten function involved in DNA
damage repair is studied by using the dynamical system approach. Detailed bifurcations of …

Stabilization of p53 protein is an important step in the activation of its function. p53 levels are
regulated by ubiquitin-dependent and-independent degradation pathways. MDM4 (MDMX) …

The Direct Computer Mapping based generation of executable multiscale hybrid process
architectures is described in the paper. We show that process models can be generated …