Abnormal enzyme expression and activity is a hallmark of many diseases. Activity-based
diagnostics are a class of chemical probes that aim to leverage this dysregulated metabolic …

The discovery of β-lactam (BL) antibiotics in the early 20th century represented a remarkable
advancement in human medicine, allowing for the widespread treatment of infectious …

β-Lactamase positive bacteria represent a growing threat to human health because of their
resistance to commonly used antibiotics. Therefore, development of new diagnostic methods …

The alarming increase of antimicrobial resistance urges rapid diagnosis and pathogen
specific infection management. This work reports a rapid screening assay for pathogenic …

The spread of antimicrobial resistance (AMR) is a rapidly growing threat to humankind on
both regional and global scales. As countries worldwide prepare to embrace a One Health …

The misuse of antibiotics in health care has led to increasing levels of drug resistant
infections (DRI's) occurring in the general population. Most technologies developed for the …

The increasing prevalence of extended spectrum β-lactamases (ESBLs) and plasmid-
mediated AmpC (pAmpC) β-lactamases among Enterobacterales threatens our ability to …

A superbly illustrated review presents the current molecular-level understanding of the key
structural complexes of the Gram-positive bacterium using Streptococcus pneumoniae as …

Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria (GNB) are
increasingly identified as the cause of both community and healthcare-associated urinary …

Antimicrobial resistance (AMR) has been identified as a major threat to public health
worldwide. To ensure appropriate use of existing antibiotics, rapid and reliable tests of AMR …