TRPM channels in health and disease
Different cell channels and transporters tightly regulate cytoplasmic levels and the
intraorganelle distribution of cations. Perturbations in these processes lead to human …
intraorganelle distribution of cations. Perturbations in these processes lead to human …
Sperm ion transporters and channels in human asthenozoospermia: genetic etiology, lessons from animal models, and clinical perspectives
E Cavarocchi, M Whitfield, F Saez, A Touré - International journal of …, 2022 - mdpi.com
In mammals, sperm fertilization potential relies on efficient progression within the female
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …
[PDF][PDF] Magnesium Disorders
Magnesium-specific carriers were originally identified in the 1950s in bacteria, fungi, and
yeast. 15, 16 But it was some 50 years later that magnesiumselective transporters were …
yeast. 15, 16 But it was some 50 years later that magnesiumselective transporters were …
Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes
In the mammalian brain TRPC channels, a family of Ca 2+-permeable cation channels, are
involved in a variety of processes from neuronal growth and synapse formation to transmitter …
involved in a variety of processes from neuronal growth and synapse formation to transmitter …
[HTML][HTML] Recent advances in the structural biology of Mg2+ channels and transporters
Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …
and are essential for various physiological processes, including ATP utilization and the …
PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics
S Hardy, Y Zolotarov, J Coleman… - Proceedings of the …, 2023 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2,
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …
[HTML][HTML] Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7
A Rössig, K Hill, W Noerenberg, S Weidenbach… - Cell Calcium, 2022 - Elsevier
The transient receptor potential cation channel, subfamily M, members 6 and 7 (TRPM6 and
TRPM7) are homologous membrane proteins encompassing cation channel units fused to …
TRPM7) are homologous membrane proteins encompassing cation channel units fused to …
Beyond Ion Homeostasis: Hypomagnesemia, Transient Receptor Potential Melastatin Channel 7, Mitochondrial Function, and Inflammation
M Liu, SC Dudley Jr - Nutrients, 2023 - mdpi.com
As the second most abundant intracellular divalent cation, magnesium (Mg2+) is essential
for cell functions, such as ATP production, protein/DNA synthesis, protein activity, and …
for cell functions, such as ATP production, protein/DNA synthesis, protein activity, and …
Magnesium reabsorption in the kidney
JHF de Baaij - American Journal of Physiology-Renal …, 2023 - journals.physiology.org
Mg2+ is essential for many cellular and physiological processes, including muscle
contraction, neuronal activity, and metabolism. Consequently, the blood Mg2+ concentration …
contraction, neuronal activity, and metabolism. Consequently, the blood Mg2+ concentration …
[HTML][HTML] Investigation of the effects of downregulation of jumping translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in …
MCF7 is a commonly used luminal type A non-invasive/poor-invasive human breast cancer
cell line that does not usually migrate or invade compared with MDA-MB-231 highly …
cell line that does not usually migrate or invade compared with MDA-MB-231 highly …