Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth
and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …

Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential
events. To ensure the dynamic nature of these molecular and morphological transitions, a …

DNA damage response, DNA repair and genomic instability have been under study for their
role in tumor initiation and progression for many years now. More recently, next-generation …

Replication-coupled DNA repair and damage tolerance mechanisms overcome replication
stress challenges and complete DNA synthesis. These pathways include fork reversal …

Schlafen-11 (SLFN11) inactivation in∼ 50% of cancer cells confers broad chemoresistance.
To identify therapeutic targets and underlying molecular mechanisms for overcoming …