In contrast to other fat-soluble vitamins, dietary vitamin K is rapidly lost to the body resulting
in comparatively low tissue stores. Deficiency is kept at bay by the ubiquity of vitamin K in the …

Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification,
which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is …

Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the
key enzyme for vitamin K–dependent carboxylation, a posttranslational modification that is …

Background: Effective involvement of VKORC1L1 in vitamin K epoxide reductase activity,
target of vitamin K antagonists (VKAs), is still unclear. Results: VKORC1L1 is not inhibited by …

Vitamin K epoxide reductase (VKOR) catalyzes the reduction of vitamin K quinone and
vitamin K 2, 3-epoxide, a process essential to sustain γ-carboxylation of vitamin K …

Anticoagulant rodenticides are commonly used to control rodent pests worldwide. They
specifically inhibit the vitamin K epoxide reductase (VKORC 1), which is an enzyme …

Dicoumarol, a symmetrical biscoumarin can be considered as the “parent” of the widely
used anticoagulant drug, warfarin. The discovery of dicoumarol's bioactive properties …

The widespread use of pesticides to control agricultural pests is a hot topic on the public
scene of environmental health. Selective pest control for minimum environmental impact is a …

Background Single nucleotide polymorphisms in the vitamin K epoxide reductase (VKOR)
gene have been successfully used for warfarin dosage prediction. However, warfarin …

Vitamin K family molecules—phylloquinone (K1), menaquinone (K2), and menadione (K3)—
act as γ-glutamyl carboxylase (GGCX)-exclusive cofactors in their hydroquinone state …