Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Abstract The theme of World Kidney Day 2017 is' kidney disease and obesity: healthy
lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five …

Few people now reach old age without taking multiple drugs, often attending various clinics,
and undergoing secondary or tertiary investigations. Most chronic conditions are, to differing …

Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains
unclear whether there are similar causal effects of obesity traits on other non-communicable …

Identification of sequence variants robustly associated with predisposition to diabetic kidney
disease (DKD) has the potential to provide insights into the pathophysiological mechanisms …

Population structure and lifestyles may have contributed to the epidemiological status of
Chronic Kidney Disease due to Type 2 Diabetes (CKD-T2D). This study is a secondary data …

Objective Obesity is a global public health challenge and strongly associated with type 2
diabetes (T2D), but its burden and effects are not well understood in people with type 1 …

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of
diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited …