Chromogranin A (CgA), a major component of the chromaffin granules, is co-stored and co-
released with catecholamines. It is also expressed in extra-adrenal sites, including the heart …

OBJECTIVE: This study was designed to investigate whether IL-17 can regulate the
expression of the MMP/TIMP system, the OPG/RANK/RANKL system, or type-I and type-III …

Cardiac remodeling in response to pressure overload involves reorganization of the
myocytes and extracellular matrix (ECM). Neurohormonal pathways have been described as …

Objective: Gallic acid, a natural chemical found in plants, has been reported to show
antioxidant, anticancer, and anti-inflammatory effects. We investigated the efficacy of a short …

Background—Studies in isolated cardiomyocytes showed that replenishment in cellular
glutathione, achieved with the glutathione precursor N-acetylcysteine (NAC), abrogated …

Reduced activity and expression of endothelial NO synthase (eNOS) is observed in
cardiomyocytes from pressure-overloaded hearts with heart failure. The present study was …

Aim: We investigated, whether the substrate for nitric oxide (NO) formation–l‐arginine–and
the aldosterone receptor antagonist–spironolactone–are able to reverse alterations of the …

The renal and cardiac benefits of renin-angiotensin system (RAS) inhibition in hypertension
exceed those attributable to blood pressure reduction, and seem to involve mitochondrial …

The mechanism of celecoxib cardiovascular adverse events was earlier investigated; yet in-
depth investigations are needed to assess the involvement of its pro-apoptotic effect …

Background The role of angiotensin II type 1 (AT 1) and type 2 (AT 2) receptors in cardiac
hypertrophy and fibrosis is incompletely understood. The availability of AT 2 receptor …