Neurons are highly polarized cells with apparent functional and morphological differences
between dendrites and axon. A critical determinant for the molecular and functional identity …

In many peripheral and central neurons, A-type K+ currents, IA, have been identified and
shown to be key determinants in shaping action potential waveforms and repetitive firing …

Voltage-gated K+ (Kv) channels regulate membrane potential in many cell types. Although
the channel surface density and location must be well controlled, little is known about Kv …

Homeostatic plasticity is engaged when neurons need to stabilize their synaptic strength
and excitability in response to acute or prolonged destabilizing changes in global activity …

A specialized axonal ending, the basket cell “pinceau,” encapsulates the Purkinje cell axon
initial segment (AIS), exerting final inhibitory control over the integrated outflow of the …

Midbrain dopamine neurons (DANs) regulate various brain functions such as motor control
and motivation. Alteration of spiking activities of these neurons could contribute to severe …

In animal models of LGI1-dependent autosomal dominant lateral temporal lobe epilepsy, Kv
1 channels are downregulated, suggesting their crucial involvement in epileptogenesis. The …

In myelinated fibers, the voltage-gated sodium channels Nav1 are concentrated at the nodal
gap to ensure the saltatory propagation of action potentials. The voltage-gated potassium …

Diversity in the functional expression of ion channels contributes to the unique patterns of
activity generated in visceral sensory A-type myelinated neurons versus C-type …

Developmental plasticity in spiral ganglion neurons (SGNs) ensues from profound
alterations in the functional properties of the developing hair cell (HC). For example …