The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the
soma and dendrites, and in some cases the axon initial segments, in sub‐populations of …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

The response of neuronal growth cones to axon guidance cues depends on the
developmental context in which these cues are encountered. We show here that the …

Inhibition by several inhibitory molecules on oligodendrocytes, and by chondroitin sulphate
proteoglycans and semaphorins in the glial scar discourages regeneration of axons in the …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …

Several molecules inhibit axonal growth cones and may account for the failure of central
nervous system regeneration, including myelin proteins and various chondroitan sulfate …

Injuries to the spinal cord that result in disruption of axonal continuity have devastating
consequences for injured patients. Current therapies that use biologically active agents to …

NG2 is purportedly one of the most growth-inhibitory chondroitin sulfate proteoglycans
(CSPGs) produced after spinal cord injury. Nonetheless, once the severed axon tips dieback …

Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …