Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Phage display libraries: from binders to targeted drug delivery and human therapeutics

M Sioud - Molecular biotechnology, 2019 - Springer
The application of repertoire selection technologies for the study and characterization of
tumor heterogeneity is an area of great interest in the field of tumor biology and …

Cognizance of molecular methods for the generation of mutagenic phage display antibody libraries for affinity maturation

CC Lim, YS Choong, TS Lim - International journal of molecular sciences, 2019 - mdpi.com
Antibodies leverage on their unique architecture to bind with an array of antigens. The
strength of interaction has a direct relation to the affinity of the antibodies towards the …

Development of a phage display panning strategy utilizing crude antigens: isolation of MERS-CoV nucleoprotein human antibodies

CC Lim, PCY Woo, TS Lim - Scientific reports, 2019 - nature.com
Antibody phage display has been pivotal in the quest to generate human monoclonal
antibodies for biomedical and research applications. Target antigen preparation is a main …

Infectious disease antibodies for biomedical applications: A mini review of immune antibody phage library repertoire

JY Lai, TS Lim - International journal of biological macromolecules, 2020 - Elsevier
Antibody phage display is regarded as a critical tool for the development of monoclonal
antibodies for infectious diseases. The different classes of antibody libraries are classified …

Antibody Phage Display

A Nur, M Schubert, JY Lai, M Hust, YS Choong… - Phage Display: Methods …, 2023 - Springer
The application of antibodies has transcended across many areas of work but mainly as a
research tool, for diagnostic and for therapeutic applications. Antibodies are immunoproteins …

A novel approach in treatment of tuberculosis by targeting drugs to infected macrophages using biodegradable nanoparticles

Shivangi, LS Meena - Applied biochemistry and biotechnology, 2018 - Springer
Mycobacterium tuberculosis, the causative agent of tuberculosis is now causing death of
more than 10 million people. Because of the development of drug-resistant TB, drug delivery …

Bacteriophages: cancer diagnosis, treatment, and future prospects

F Abbaszadeh, HE Leylabadlo, F Alinezhad… - Journal of …, 2021 - Springer
Background Early diagnosis is one of the most important factors in cancer treatment.
Unfortunately, despite remarkable advances in the diagnosis and treatment methods of …

TCR-like domain antibody against Mycobacterium tuberculosis (Mtb) heat shock protein antigen presented by HLA-A* 11 and HLA-A* 24

SA Dass, MN Norazmi, A Acosta, ME Sarmiento… - International journal of …, 2020 - Elsevier
T cell receptor (TCR)-like antibodies, obtained with the use of phage display technology,
sandwich the best of the both arms of the adaptive immune system. In this study, in vitro …

[HTML][HTML] A scFv phage targeting the C. albicans cell wall screened from a bacteriophage-based library of induced immune protection in mice

X Zhang, S Dong, Y Huang, H Shi, X Chen… - Infection, Genetics and …, 2022 - Elsevier
C. albicans is the most prevalent opportunistic fungal and can cause life-threatening
systemic infections under certain circumstances. The inefficiency and resistance of …