In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Background Research suggests that measurable change in cerebrospinal fluid (CSF)
biomarkers occurs years in advance of the onset of clinical symptoms (Beckett 2010). In this …

Political drive to screen for pre-dementia: not evidence based and ignores the harms of
diagnosis Page 1 TOO MUCH MEDICINE Political drive to screen for pre-dementia: not …

Background: Cognitive enhancers, including cholinesterase inhibitors and memantine, are
used to treat dementia, but their effectiveness for mild cognitive impairment is unclear. We …

This article presents recommendations, based on the Grading of Recommendations,
Assessment, Development, and Evaluation method, for the clinical application of …

Objective: To provide guidance on standards for reporting studies of diagnostic test accuracy
for dementia disorders. Methods: An international consensus process on reporting …

Background According to the latest revised National Institute of Neurological and
Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders …

Biomarkers have been described as characteristics, most often molecular, that provide
information about biological states, whether normal, pathological, or therapeutically …