Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR

T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

[HTML][HTML] Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR

ASL Thankamony, JJ Wittmann, M Kaushik… - Progress in nuclear …, 2017 - Elsevier
The field of dynamic nuclear polarization has undergone tremendous developments and
diversification since its inception more than 6 decades ago. In this review we provide an in …

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

MT Colvin, R Silvers, QZ Ni, TV Can… - Journal of the …, 2016 - ACS Publications
Amyloid-β (Aβ) is a 39–42 residue protein produced by the cleavage of the amyloid
precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that …

Biomolecular and biological applications of solid-state NMR with dynamic nuclear polarization enhancement

WY Chow, G De Paëpe, S Hediger - Chemical Reviews, 2022 - ACS Publications
Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Solid-state NMR dipolar and chemical shift anisotropy recoupling techniques for structural and dynamical studies in biological systems

L Liang, Y Ji, K Chen, P Gao, Z Zhao, G Hou - Chemical Reviews, 2022 - ACS Publications
With the development of NMR methodology and technology during the past decades, solid-
state NMR (ssNMR) has become a particularly important tool for investigating structure and …

Nuclear depolarization and absolute sensitivity in magic-angle spinning cross effect dynamic nuclear polarization

F Mentink-Vigier, S Paul, D Lee, A Feintuch… - Physical Chemistry …, 2015 - pubs.rsc.org
Over the last two decades solid state Nuclear Magnetic Resonance has witnessed a
breakthrough in increasing the nuclear polarization, and thus experimental sensitivity, with …

[HTML][HTML] Focus: the aging brain: amyloid-beta Alzheimer targets—protein processing, lipid rafts, and amyloid-beta pores

M LaFontaine, M Cumbay - The Yale journal of biology and …, 2016 - ncbi.nlm.nih.gov
Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious
in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen …

Theoretical aspects of magic angle spinning-dynamic nuclear polarization

F Mentink-Vigier, U Akbey, H Oschkinat, S Vega… - Journal of Magnetic …, 2015 - Elsevier
Abstract Magic Angle Spinning (MAS) combined with Dynamic Nuclear Polarization (DNP)
has been proven in recent years to be a very powerful method for increasing solid-state …

Magic Angle Spinning NMR of Proteins: High-Frequency Dynamic Nuclear Polarization and 1H Detection

Y Su, L Andreas, RG Griffin - Annual review of biochemistry, 2015 - annualreviews.org
Magic angle spinning (MAS) NMR studies of amyloid and membrane proteins and large
macromolecular complexes are an important new approach to structural biology. However …

Mechanisms of dynamic nuclear polarization in insulating solids

TV Can, QZ Ni, RG Griffin - Journal of Magnetic Resonance, 2015 - Elsevier
Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensities in
NMR experiments by transferring the high polarization of electrons to their surrounding …