Cancer therapy is a growing field, and annually, a high number of research is performed to
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …

Circadian rhythms are essential to physiological homeostasis, but often disrupted in the
intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to …

Alzheimer's disease (AD) is presented as an age-related neurodegenerative disease with
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …

Aims We investigate the effect of nobiletin on vascular and renal alterations and possible
mechanisms involved in high-fat diet (HFD)-fed rats. Main methods Male Sprague-Dawley …

Background: Ischemia–reperfusion injury (IRI) is one of the main causes of acute kidney
injury. Our previous results have shown that anti-oxidative stress decreased in the renal IRI …

Introduction: Remote ischemic conditioning upregulates endogenous protective pathways in
response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote …

Nobiletin was found to protect against acute myocardial infarction (AMI)‐induced cardiac
function decline and myocardial remodeling, although the dose–effect relationship and …

Fructus Aurantii (FA) is a traditional herbal medicine that has been widely used for
thousands of years in China and possesses a variety of pharmacological effects. However …

Ischemia/reperfusion injury (IRI) during kidney transplantation is a serious clinical problem
with a high mortality rate and a lack of therapy. Therefore, there is a need to improve the …

Drug-induced nephrotoxicity is a frequent adverse event that contributes to acute kidney
injury with tubular and/or glomerular lesions. Methotrexate (MTX) is a folate analog used …