Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Aristolochic acid-associated cancers: a public health risk in need of global action
S Das, S Thakur, M Korenjak, VS Sidorenko… - Nature Reviews …, 2022 - nature.com
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
The repertoire of mutational signatures in human cancer
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
[HTML][HTML] A compendium of mutational signatures of environmental agents
Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …
mutation patterns that hint at the causative origins of cancer. We examined mutational …
The mutational signature profile of known and suspected human carcinogens in mice
Epidemiological studies have identified many environmental agents that appear to
significantly increase cancer risk in human populations. By analyzing tumor genomes from …
significantly increase cancer risk in human populations. By analyzing tumor genomes from …
The genome as a record of environmental exposure
S Nik-Zainal, JE Kucab, S Morganella, D Glodzik… - …, 2015 - academic.oup.com
Whole genome sequencing of human tumours has revealed distinct patterns of mutation that
hint at the causative origins of cancer. Experimental investigations of the mutations and …
hint at the causative origins of cancer. Experimental investigations of the mutations and …
The repertoire of mutational signatures in human cancer
Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …
Next-generation DNA damage sequencing
Cellular DNA is constantly chemically altered by exogenous and endogenous agents. As all
processes of life depend on the transmission of the genetic information, multiple biological …
processes of life depend on the transmission of the genetic information, multiple biological …
In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic
mutations, called a mutational signature. Despite widespread use of cisplatin in cancer …
mutations, called a mutational signature. Despite widespread use of cisplatin in cancer …
A comprehensive survey of the mutagenic impact of common cancer cytotoxics
B Szikriszt, Á Póti, O Pipek, M Krzystanek, N Kanu… - Genome biology, 2016 - Springer
Background Genomic mutations caused by cytotoxic agents used in cancer chemotherapy
may cause secondary malignancies as well as contribute to the evolution of treatment …
may cause secondary malignancies as well as contribute to the evolution of treatment …