Advances in the cellular biology, biochemistry, and molecular biology of acidocalcisomes

R Docampo - Microbiology and Molecular Biology Reviews, 2024 - Am Soc Microbiol
Acidocalcisomes are organelles conserved during evolution and closely related to the so-
called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of …

Biological activity of aminophosphonic acids and their short peptides

B Lejczak, P Kafarski - Phosphorous Heterocycles I, 2009 - Springer
The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

A Mucha, P Kafarski, Ł Berlicki - Journal of Medicinal Chemistry, 2011 - ACS Publications
R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Machine learning approach for prediction of reaction yield with simulated catalyst parameters

A Yada, K Nagata, Y Ando, T Matsumura… - Chemistry …, 2018 - academic.oup.com
Prediction of reaction yields by machine learning approach is demonstrated in tungsten-
catalyzed epoxidation of alkenes. The various electronic and vibrational parameters of the …

Model systems for studying polyphosphate biology: a focus on microorganisms

A Denoncourt, M Downey - Current Genetics, 2021 - Springer
Polyphosphates (polyP) are polymers of inorganic phosphates joined by high-energy bonds
to form long chains. These chains are present in all forms of life but were once disregarded …

New insights into the role of acidocalcisomes in trypanosomatids

R Docampo, G Huang - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
Acidocalcisomes are electron‐dense organelles rich in polyphosphate and inorganic and
organic cations that are acidified by proton pumps, and possess several channels, pumps …

The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites

R Docampo, SNJ Moreno - Current pharmaceutical design, 2008 - ingentaconnect.com
Acidocalcisomes are acidic organelles rich in calcium and phosphorus that have been
conserved from bacteria to man. In parasitic protozoa acidocalcisomes possess enzymes …

N-heterocyclic dronic acids: applications and synthesis

H R. Hudson, N J. Wardle, S WA Bligh… - Mini reviews in …, 2012 - benthamdirect.com
Substituted hydroxymethylenebisphosphonic acid derivatives–either as dronic acids or their
dronate sodium salts, are important pharmaceuticals in the treatment of diseases arising …

Isoprenoid Biosynthesis as a Drug Target:  Bisphosphonate Inhibition of Escherichia coli K12 Growth and Synergistic Effects of Fosmidomycin

A Leon, L Liu, Y Yang, MP Hudock, P Hall… - Journal of medicinal …, 2006 - ACS Publications
We screened a library of 117 bisphosphonates for antibacterial activity against Escherichia
coli. The most potent growth inhibitors where the N-[methyl (4-phenylalkyl)]-3-aminopropyl-1 …

[PDF][PDF] The development of bisphosphonates for therapeutic uses, and bisphosphonate structure-activity consideration.

WM Abdou, AA Shaddy - ARKIVOC: Online Journal of …, 2009 - pdfs.semanticscholar.org
Recent progress in the synthesis of major constituents of the methyl-1, 1-bisphosphonate
family is reviewed. These compounds are important precursors of the corresponding …