RecA and DNA recombination: a review of molecular mechanisms

E Del Val, W Nasser, H Abaibou… - Biochemical Society …, 2019 - portlandpress.com
Recombinases are responsible for homologous recombination and maintenance of genome
integrity. In Escherichia coli, the recombinase RecA forms a nucleoprotein filament with the …

Mechanism of strand exchange from RecA–DNA synaptic and D-loop structures

H Yang, C Zhou, A Dhar, NP Pavletich - Nature, 2020 - nature.com
The strand-exchange reaction is central to homologous recombination. It is catalysed by the
RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) …

[HTML][HTML] Commensal Neisseria kill Neisseria gonorrhoeae through a DNA-dependent mechanism

WJ Kim, D Higashi, M Goytia, MA Rendón… - Cell host & …, 2019 - cell.com
The mucosa is colonized with commensal Neisseria. Some of these niches are sites of
infection for the STD pathogen Neisseria gonorrhoeae (Ngo). Given the antagonistic …

Direct single-molecule observation of mode and geometry of RecA-mediated homology search

AJ Lee, M Endo, JK Hobbs, C Wälti - Acs Nano, 2018 - ACS Publications
Genomic integrity, when compromised by accrued DNA lesions, is maintained through
efficient repair via homologous recombination. For this process the ubiquitous recombinase …

Micro-homology intermediates: RecA's transient sampling revealed at the single molecule level

AJ Lee, M Endo, JK Hobbs, AG Davies… - Nucleic Acids …, 2021 - academic.oup.com
Recombinase A (RecA) is central to homologous recombination. However, despite
significant advances, the mechanism with which RecA is able to orchestrate a search for …

[HTML][HTML] DNA nanostructures: A versatile lab-bench for interrogating biological reactions

AJ Lee, C Wälti - Computational and Structural Biotechnology Journal, 2019 - Elsevier
At its inception DNA nanotechnology was conceived as a tool for spatially arranging
biological molecules in a programmable and deterministic way to improve their …

Development of time-resolved cryo-EM and studying the mechanism of homology search by the RecA recombinase

ME Mäeots - 2023 - discovery.ucl.ac.uk
Structural determination and analysis have become increasingly prominent in recent years.
At the forefront of this development has been the progress of cryo-electron microscopy …

Imaging & Microscopy

X Lei, E Xiao - Physics World, 1995 - iopscience.iop.org
(SEM) that achieves outstanding resolution, particularly at the low beam energies often
required in the life sciences. The DSM 982 GEMINI is capable of achieving lateral resolution …

[引用][C] The origin of life is rhythmic repair or Macrocosmic rhythms created life: To survive, complementary primordial life molecules had to become self-repairing timers …

R Frey - 2023 - tredition