Bacterial biofilms represent multicellular communities embedded in a matrix of extracellular
polymeric substances, conveying increased resistance against environmental stress factors …

Although immunoglobulin G (IgG) harbors just one N-glycosylation site per heavy chain, this
glycosylation plays a key role in modulating its function. In human serum, IgG is classified …

Streptococcal pyrogenic exotoxin B (SpeB) is a cysteine protease expressed during group A
streptococcal infection that represents a major virulence factor. Although subject to several …

Human antibodies are heterogeneous molecules primarily due to clonal sequence
variations. Analytical techniques to assess antibody levels quantitatively, such as ELISA …

Since the introduction of Quality by Design for production of biopharmaceuticals, the global
biopharma industry has been advancing towards developing highly efficient and sensitive …

The conserved region (Fc) of IgG antibodies dictates the interactions with designated
receptors thus defining the immunological effector functions of IgG. Amino acid sequence …

In view of the worldwide antimicrobial resistance (AMR) threat, new bacterial targets and anti-
infective agents are needed. Since important roles in bacterial pathogenesis have been …

Human immunoglobulin G (IgG), which is a major class of globulin antibodies with a typical
immunoglobulin monomer structure, is mainly involved in immune activities such as binding …

Disulfide bond reduction within antibody mass spectrometry workflows is typically carried out
using chemical reducing agents to produce antibody subunits for middle-down and middle …

While primarily found in endo-lysosomal compartments, the cysteine protease legumain can
also translocate to the cell surface if stabilized by the interaction with the RGD-dependent …