Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis
L MacDonald, A Elmesmari, D Somma, J Frew… - Immunity, 2024 - cell.com
Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating
dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to …
dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to …
hadge: a comprehensive pipeline for donor deconvolution in single-cell studies
Single-cell multiplexing techniques (cell hashing and genetic multiplexing) combine multiple
samples, optimizing sample processing and reducing costs. Cell hashing conjugates …
samples, optimizing sample processing and reducing costs. Cell hashing conjugates …
Benchmarking single-cell hashtag oligo demultiplexing methods
Sample multiplexing is often used to reduce cost and limit batch effects in single-cell RNA
sequencing (scRNA-seq) experiments. A commonly used multiplexing technique involves …
sequencing (scRNA-seq) experiments. A commonly used multiplexing technique involves …
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
J Nyirenda, OM Hardy, JD Silva Filho, V Herder… - Nature Medicine, 2024 - nature.com
Postmortem single-cell studies have transformed understanding of lower respiratory tract
diseases (LRTDs), including coronavirus disease 2019 (COVID-19), but there are minimal …
diseases (LRTDs), including coronavirus disease 2019 (COVID-19), but there are minimal …
A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq
DV Brown, CJA Anttila, L Ling, P Grave, TM Baldwin… - Genomics, 2024 - Elsevier
Single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for
understanding cellular heterogeneity and function. However the choice of sample …
understanding cellular heterogeneity and function. However the choice of sample …
Systematic benchmark of single-cell hashtag demultiplexing approaches reveals robust performance of a clustering-based method
Single-cell technology opened up a new avenue to delineate cellular status at a single-cell
resolution and has become an essential tool for studying human diseases. Multiplexing …
resolution and has become an essential tool for studying human diseases. Multiplexing …
hadge: a comprehensive pipeline for donor deconvolution in single cell
Single cell multiplexing techniques (cell hashing and genetic multiplexing) allow to combine
multiple samples, thereby optimizing sample processing and reducing batch effects. Cell …
multiple samples, thereby optimizing sample processing and reducing batch effects. Cell …
Robust and cost-efficient single-cell sequencing through combinatorial pooling
Single-cell sequencing is widely used to study molecular cell-to-cell heterogeneity. Even
though the cost of sequencing has dropped throughout the last decades, single-cell assays …
though the cost of sequencing has dropped throughout the last decades, single-cell assays …
demuxSNP: supervised demultiplexing single-cell RNA sequencing using cell hashing and SNPs
Background Multiplexing single-cell RNA sequencing experiments reduces sequencing cost
and facilitates larger-scale studies. However, factors such as cell hashing quality and class …
and facilitates larger-scale studies. However, factors such as cell hashing quality and class …