Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of
age-related phenotypes, and increase the risk for skin cancer—a phenomenon defined as …

Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line
defenders in the anti-tumor response. To prevent tumor development, NK cells are …

Senescent cells accumulate in human tissues during ageing and contribute to age-related
pathologies. The mechanisms responsible for their accumulation are unclear. Here we show …

Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical
class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections …

Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …

Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

HLA-E is a nonclassical HLA class I molecule, which differs from classical HLA molecules by
its nonpolymorphic, conserved nature. Expression and function of HLA-E in normal tissues …

Background The presentation of HLA peptide complexes to T cells is a highly regulated and
tissue specific process involving multiple transcriptionally controlled cellular components …

Growing neoplasms employ various mechanisms to evade immunosurveillance. The
expression of non-classical MHC class I molecules by both immune and malignant cells in …