Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

Skin has been reported to reflect the general inner-health status and aging. Nutrition and its
reflection on skin has always been an interesting topic for scientists and physicians …

For a number of years, coenzyme Q (CoQ 10 in humans) was known for its key role in
mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular …

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant
activity, and an increase in oxidative stress, marked by an increase in reactive oxygen …

According to the widely acknowledged mitochondrial free radical theory of aging (MFRTA),
the macromolecular damage that results from the production of toxic reactive oxygen …

Aging skeletal muscles are characterized by a progressive decline in muscle mass and
muscular strength. Such muscular dysfunctions are usually associated with structural and …